Motor Neuron Disease
(Amyotrophic Lateral Sclerosis (ALS))
Motor neuron disease (MND) is a progressive condition characterised by degeneration of upper and lower motor neurons.
The term AMYOTROPHIC LATERAL SCLEROSIS (ALS) is used synonymously with motor neuron disease.
Motor neuron disease (MND) is a progressive condition characterized by degeneration of upper and lower motor neurons.
The term AMYOTROPHICLATERAL SCLEROSIS (ALS) is used synonymously with motor neuron disease.
CAUSES OF MND:
According to Dr.S.KPATHAK The causes of motor neuron disease is100% neurologicalproblems.
Mutations in the SOD1gene (responsible for producing the enzyme superoxide dismutase)are found in20% of familial cases of ALS. Defects in the enzyme lead to accumulation and anterior horn cell death.
Chronic virus infection has been suggested. Polio virus will acutely damage the anterior horn cells and chronic polio infection could theoretically produce motor neuron disease.
Certain metals, lead, selenium, mercury and manganese have been incriminated, but a gain evidence is inconclusive.
Clinical similarities between MND and neurological involvement in hyperparathyroidism and phosphate deficiency suggest a relationship with chronic calcium deficiency. Abnormal-clumps of proteins (neurofilament) can be found in motor neurons that may them selves be toxic or by-products of overwhelming cell injury.
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