 |
|
Stomach, Abdominal And Digestive Problems |
 |
| Contrary to common belief, lifestyle factors do not play a major role in the development of GERD. In the majority of people with reflux disease, the dominant mechanism of symptom production is through contact of the esophageal mucosa with gastric acid and pepsin [3]3. Dent J, Brun J, Fendrick A, Fennerty M, Janssens J, Kahrilas P et al. on behalf of the Genval Workshop Group. An evidence-based appraisal of reflux disease management – the Genval Workshop Report. Gut 1999;44 Suppl 2:S1–15. close . Normally, the stomach contents are prevented from refluxing into the esophagus by a ring of muscle, the lower esophageal sphincter (LES). This acts as a one-way valve, which allows food to enter the stomach but not to exit the same way. Sometimes the LES is not completely effective and allows the stomach contents back into the esophagus, where gastric acid and pepsin can cause irritation to the esophageal mucosa. Damage to the esophagus caused by gastric acid and pepsin refluxing through the LES is usually minimised through a number of mucosal defence systems. However, when these mechanisms are impaired or overwhelmed, GERD symptoms may result. |
| View Patient |
|
 |
